Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines

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Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines

Viral vaccine vectors have shown to be effective in inducing a robust immune response against the vaccine antigen. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising vaccine vector against human and veterinary pathogens. Avirulent NDV strains LaSota and B1 have long track records of safety and efficacy. Therefore, use of these strains as vaccine vectors is highly safe in avia...

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Newcastle disease (ND) is one of the most serious illnesses of chickens. Live vaccines are widely used to prevent chicken from the disease all over the world. To access the effective and potentiate ND vaccine, a homogenous subpopulation from LaSota strain was selected following cultivation of the virus on primary chicken embryofibroblast (CEF) cells. Pathogenicity indices and molecular characte...

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ژورنال

عنوان ژورنال: Viruses

سال: 2016

ISSN: 1999-4915

DOI: 10.3390/v8070183